BioMedical Eng Services

BIOMEDICAL ENGINEERING SERVICES

Biomedical engineering is the application of engineering principles to biological systems for healthcare. Biomedical Imaging devices such as X-ray, Magnetic Resonance Imaging (MRI), Computer Tomography (CT) and Ultrasound (UT) , and therapeutic devices such as Electromagnetic (RF, MW, AC, DC)  ablation, Ultrasound, robotic surgery  provided significant growth to healthcare industry. Convergence of Nano, bio, info and cognitive science is the growth trend in healthcare. Bioengineering, Bio Computer Aided Engineering (BioCAE) can revolutionize the diagnostic, therapy and rehabilitation. We provide virtual Biomedical engineering product design and development services.  We specialize on fulfilling the coupled functional requirements of Bio medical systems.

BioMedical Engineering Simulation Solutions

We provide basic Bio Medical engineering simulations for,

• Structural simulations of skeletal biomechanics and  crash/injury impact biomechanics.

• Multibody dynamics simulation of Terrestrial locomotion for sport, comfort and ergonomic performance.

• Fluid flow simulation for Hemodynamics, circulatory and respiratory systems.

• Bio Material design for cardiovascular  implants, artificial tissue, artificial bone, optical implants,  orthopedic implant and dental materials.

• Linear and nonlinear ultrasound propagation simulations for Ultrasonic Imaging, therapy, focussed  ultrasound probe and product design.

• Virtual product development  solutions for medical diagnostics and therapy devices

  • Ultrasonic imaging

  • Ultrasonic Therapy

  • RF ablation

  • X-ray, CT imaging

  • MRI

• Multifunctional Orthopedic and prosthetic device design

• Electromagnetic shielding and interference design for medical devices. For example, Electromagnetic interference effects of mobile phone on human and prediction of Specific Absorption Rate (SAR).

Multiphysics BioMedical Engineering Simulation Solutions

Our Speciality coupled MULTIPHYSICS CAE for Structural Engineering includes,

• Coupled fluid flow + larger deformation structural analysis of blood vessels and larger deformation biological systems.

• Tissue Ablation: Electromagnetic (RF, MW, AC/DC) and high intensity ultrasound waves  interaction on biological systems for Ablation therapy device design simulation solutions.

• Bio Electricity: Coupled Electrical and Flow simulations for device and therapy simulations levering bio electricity phenomenon.

• Bio Magnetics : Coupled Magnetic and Flow simulations for device and therapy simulations levering bio Magnetic effects.

• Bio optics : Coupled optical and Flow simulations for device and therapy simulations levering bio optics, luminesce and fluorescence effects.

Emerging Biomedical Engineering

Our focus on emerging technologies related to Biomedical Engineering are,

• Multiphysics modelling  with Nano Bio Info and Cognitive convergence for disruptive healthcare diagnostics and therapy solutions.

• Smart, connected, miniaturised  and low cost Medical diagnostics and therapeutics devices and apps.

• 3D printing of stem cells, bio tissue, skin and artificial organs.

• Bio CAE:  Computer aided engineering principles applied to biomedical device  diagnostics and therapy development leveraging virtual product development.

ATOA’s  New addition to  Bio Medical Engineering Solutions,

• 3D Printing of Bio medical models and Bio materials.

• BioMedical Engineering design apps for material, process and performance parameters prediction for X-ray, MR and Ultrasound.

The innovation breakthroughs are happening at the boundary of core and established technologies. Biomedical Engineering is an interdisciplinary technology and hence inherently can fuel many technological innovations.  Our multidisciplinary expertise helps to develop novel application by exploiting the multiphysics synergy for client benefits.  We provide simulation services on the engineering and multiphysics aspects of chemical, biological and medical system. At ATOA, Computational Biomedical Mechanics for product innovation for our clients is the ultimate objective.   

Contact ATOA for advanced  Biomedical Engineering simulation solutions at  cae@atoa.com

Biomedical mechanics keywords

Biomedical Applications: Biomedical, Orthosis, Prosthesis, Implants, Healthcare, Diagonics, Therapy, Ultrasound, X-ray, MRI, Echo, ECG, Digital stethoscopes, Chestbelt, Computed Tomography, 3D vision, Computer-Integrated Surgery, Medical Robotics, Bioscience, BioCAE, Bio heat Transfer, Hemodynamics, Respiratory Mechanics, Biomechanics, Biodynamics, Bone Mechanics, Biopolymers, Biomedical Composites, Bio ceramics, Biomaterials, Bioelectricity, Bio magnetics, Prosthetics, Rehabilitators, Clinical Engineering, Tissue Engineering, Biomedical 3D printing

Basis: Anatomy, Physiology, Homeostasis, , Cell, Cell membrane, Nucleus, Cytoplasm, Mitochondria, DNA, RNA, Proteins, Enzymes, Gene expression, Stem cells, Apoptosis, Mutation, Blood pressure, Heart rate, Oxygen saturation, Body temperature, Glucose level, Infection, Inflammation, Cancer, Diabetes, Hypertension, Stroke, Genetic disorders, Autoimmune diseases, Vaccine, Antibiotics, Chemotherapy, Immunotherapy, Gene therapy, Radiation therapy, Clinical trials, Epidemiology, Biostatistics, Bioinformatics, Molecular diagnostics, Personalized medicine.

Computational Biomedical Mechanics

Introduction to Biomedical Mechanics

Biomedical engineering applies principles from various engineering disciplines—such as mechanical, chemical, electrical, and computational engineering—to solve problems in biology and medicine. The computational domain in biomedical engineering is vital for understanding and simulating biological systems, which are inherently complex. Computational tools are used to model processes like tissue growth, organ function, and medical device interactions, offering insights that enhance diagnostics, treatment, and medical device design.

Computational biomedical engineering involves the integration of biological data and physical principles into models that can predict behavior and inform clinical and therapeutic decisions.

Use Cases in Biomedical Engineering Mechanics

Biomedical engineering’s computational domain plays a key role in several areas:

               Medical Imaging: Simulation and analysis of MRI, CT, ultrasound, and other imaging modalities to improve diagnostics and treatment planning.

               Biomechanics: Modeling of tissues, bones, and joints to understand injury mechanisms, prosthetics, and rehabilitation strategies.

               Cardiovascular Systems: Simulating blood flow, heart function, and vascular systems to assist in designing stents, artificial valves, and pacemakers.

               Drug Delivery Systems: Simulating drug dispersion in the body to optimize the efficacy of targeted treatments and controlled-release mechanisms.

               Tissue Engineering: Computational modeling of tissue growth and regeneration to design scaffolds for tissue engineering applications, such as skin grafts or organ regeneration.

Basics of Biomedical Engineering Mechanics

Biomedical engineering draws on the mechanics of biological systems, combining knowledge from both the life sciences and engineering. Key concepts include:

·             Biomechanics: The study of forces and their effects on the human body, including musculoskeletal dynamics, joint movements, and tissue deformation. Biomechanics is used to design prosthetics, orthotics, and rehabilitation tools.

·             Biofluids: The study of fluid mechanics in biological systems, particularly in the cardiovascular, respiratory, and lymphatic systems. Biofluids is essential for understanding blood flow, oxygen transport, and drug diffusion.

·             Cell and Tissue Mechanics: The study of how cells and tissues respond to mechanical forces, critical for areas like tissue engineering, cancer research, and wound healing.

·             Electrophysiology: The study of electrical signals within biological systems, such as the heart and nervous system. This area is important for pacemaker design, brain-computer interfaces, and neuromodulation therapies.

·             Medical Device Interaction: The analysis of how medical devices, such as implants, pacemakers, and prosthetics, interact with biological systems, ensuring biocompatibility and functionality.

Types of Biomedical Engineering Analysis

Biomedical engineering analysis can be categorized based on the type of biological system or medical device being studied:

·             Cellular and Molecular Simulation: Simulates processes at the cellular or molecular level, such as drug interactions, gene expression, or protein folding. This type of analysis is critical in pharmacology and genomics.

·             Tissue-Level Simulation: Models the behavior of tissues and organs, such as mechanical deformation in bones, or blood flow in arteries. This is important for prosthetics design, surgical planning, and understanding disease progression.

·             Organ-Level Simulation: Focuses on simulating entire organ systems, such as the heart, lungs, or kidneys. These models are often used in medical device testing and treatment planning.

·             Multiphysics Simulation: Biomedical systems often involve multiple physical phenomena, such as fluid-structure interactions (e.g., blood flow and arterial walls) or electrical-mechanical interactions (e.g., the heart’s electrical activity and mechanical contraction).

Partial Differential Equations (PDEs) in Biomedical Engineering Mechanics

Many processes in biomedical engineering are governed by partial differential equations (PDEs) that describe how physical quantities—such as velocity, concentration, temperature, or electric potential—change over time and space. Common PDEs in biomedical engineering include:

·             Navier-Stokes Equations: Describes blood flow in the cardiovascular system and air flow in the respiratory system. The equations govern fluid motion by relating velocity, pressure, and viscosity.

·             Heat Equation: Describes temperature distribution in tissues, crucial in hyperthermia treatments, laser ablation, and cryotherapy.

·             Diffusion Equation: Governs the diffusion of drugs or oxygen in tissues, crucial in drug delivery system design and wound healing.

·             Poisson’s Equation: Models electrostatic potential in electrophysiology, such as the propagation of electrical signals in neurons or cardiac tissue.

·        Pennes’ Bioheat Equation

ρ c ∂T/∂t = k ∇²T + ωb cb (Tb - T) + Qm + Qext

Where:

T(x,t) = tissue temperature

ρ = tissue density

c = specific heat capacity of tissue

k = thermal conductivity of tissue

ωb = blood perfusion rate (kg blood / m³ tissue / s)

cb = specific heat of blood

Tb = arterial blood temperature (assumed constant ~ body core temp)

Qm = metabolic heat generation (W/m³)

Qext = external heat source (e.g., laser, ultrasound, electromagnetic heating)

Material Properties Required in Biomedical Engineering Mechanics

Biomedical applications require materials with specific properties to ensure compatibility and performance. Key material properties include:

·             Biocompatibility: Ensures that materials do not trigger adverse biological responses. Important for implants, prosthetics, and drug delivery systems.

·             Elasticity and Stiffness: Determines how much a material can stretch or compress. This is critical for materials used in stents, heart valves, and artificial tendons.

·             Porosity: Affects the flow of fluids through materials, important for tissue scaffolds, drug delivery systems, and dialysis membranes.

·             Conductivity: Electrical conductivity is vital in materials for biosensors, neural interfaces, and pacemakers.

·             Degradability: In some applications, materials need to degrade safely within the body, such as in sutures, tissue scaffolds, or drug delivery capsules.

Typical Product Performance Characteristics

In biomedical engineering, the performance of devices, systems, or treatments is measured using several key metrics:

·             Accuracy: How well a device or simulation predicts or replicates physiological behavior, crucial in diagnostics and treatment planning.

·             Durability: The longevity of medical implants or devices inside the body, such as prosthetics, pacemakers, or stents.

·             Efficacy: How well a treatment or device improves health outcomes, measured in clinical trials or simulations.

·             Patient Safety: Ensuring that materials and devices do not cause harm, particularly for implants and drug delivery systems.

·             Functionality: How well a device performs its intended role, such as controlling heart rhythm (pacemakers) or replacing joint movement (prosthetics).

Summary of biomedical  mechanics

The computational domain in biomedical engineering is crucial for advancing healthcare technologies and improving patient outcomes. Through the use of computational models, simulations, and numerical methods, biomedical engineers can develop innovative solutions for diagnosing, treating, and preventing diseases. With continued progress in simulation technologies and computational methods, the future of biomedical engineering holds tremendous potential for breakthroughs in personalized medicine, medical devices, and patient care.